Negative regulation of Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHF, TIGD2, and SPTSSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Notch signaling pathway activity versus EHF in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EHF →	+0.581	+0.154	.001	<.001	3	4
OV	TIGD2 →	+0.548	+0.709	.002	.006	3	4
BRCA	SPTSSB →	+1.844	+0.151	<.001	.007	3	4
UCEC	IKZF2 →	+0.452	+0.162	.002	<.001	3	3
BRCA	GALNT7 →	+1.002	+0.186	.003	<.001	3	3
LUAD	TSPAN31 →	+0.395	+0.132	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045746 vs EHF — UCEC

Explore this scatter interactively →