Negative regulation of Notch signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXA1L, RAVER2, and GNAI2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OXA1L grouped by Negative regulation of Notch signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OXA1L →	+0.395	+0.650	.001	.001	3	4
LARGE_INTESTINE	RAVER2 →	+0.990	+0.754	.004	.001	3	4
CNS	GNAI2 →	-1.000	-0.808	.005	.002	3	4
OVARY	HSPD1 →	+0.571	+0.684	.004	.007	3	4
LUNG_NSCLC_LUAD	DNAJB1 →	-0.493	-0.549	.004	.001	3	4
BREAST	CUTA →	-0.593	-0.808	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OXA1L by Negative regulation of Notch signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →