Negative regulation of Notch signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, HMCN1, and COL8A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Notch signaling pathway activity versus MMP14 in LUNG_NSCLC_LUAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MMP14 →	+3.973	+0.854	<.001	<.001	3	7
LUNG_NSCLC_LUAD	HMCN1 →	+1.513	+0.548	.003	.008	3	6
CNS	COL8A2 →	+1.564	+1.037	.004	.003	3	6
BLOOD_Leukemia	MTARC1 →	-2.578	-0.866	<.001	.001	3	5
BREAST	BSPRY →	-2.002	-0.851	.003	.008	3	5
LUNG_NSCLC_LUAD	TST →	-0.897	-0.558	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045746 vs MMP14 — LUNG_NSCLC_LUAD

Explore this scatter interactively →