Positive regulation of G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCA, GPER1, and PPP2R2C, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G protein-coupled receptor signaling pathway activity versus PRKCA in ACC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	PRKCA →	+1.581	+0.047	<.001	<.001	3	17
ACC	GPER1 →	+1.839	+0.053	<.001	.001	2	16
LGG	PPP2R2C →	+1.599	+0.062	<.001	<.001	3	14
UCS	KLK6 →	+2.568	+0.040	.007	.002	1	16
KIRP	ZNF692 →	-0.784	-0.045	<.001	<.001	3	14
BLCA	PIK3R2 →	-0.262	-0.026	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045745 vs PRKCA — ACC

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