Positive regulation of G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIPR1, EXO1, and CSE1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G protein-coupled receptor signaling pathway activity versus VIPR1 in GBM (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VIPR1 →	+0.555	+0.246	<.001	<.001	3	4
HNSC	EXO1 →	-0.699	-0.189	.004	.006	3	4
UCEC	CSE1L →	-0.772	-0.472	<.001	.002	3	4
OV	TFB2M →	-0.407	-0.213	.004	.009	3	4
OV	MZT1 →	-0.598	-0.236	.002	.006	3	4
UCEC	VRK1 →	-0.661	-0.460	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045745 vs VIPR1 — GBM

Explore this scatter interactively →