Positive regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPP1, TINF2, and TNFRSF14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPP1 grouped by Positive regulation of fibroblast growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TPP1 →	-1.235	-1.623	<.001	.001	3	6
URINARY_TRACT	TINF2 →	-0.801	-1.597	.002	<.001	3	6
LIVER	TNFRSF14 →	-2.658	-1.223	.009	.005	3	5
URINARY_TRACT	STX2 →	-1.880	-1.677	.003	<.001	3	5
URINARY_TRACT	KLC1 →	-0.890	-1.853	.008	<.001	2	6
URINARY_TRACT	ZNF280C →	-1.162	-1.866	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPP1 by Positive regulation of fibroblast growth factor receptor signaling pathway activity — LUNG_NSCLC_LUSC

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