Positive regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2N1, DLX4, and IGFBP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK2N1 grouped by Positive regulation of fibroblast growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CAMK2N1 →	-0.222	-0.118	.004	.005	3	5
LUNG_SCLC	DLX4 →	+0.190	+0.242	.008	.004	3	5
STOMACH	IGFBP7 →	-0.310	-0.262	.001	<.001	3	4
LARGE_INTESTINE	COL7A1 →	-0.195	-0.092	<.001	.009	2	5
LARGE_INTESTINE	ALDH1A3 →	-0.158	-0.118	<.001	<.001	3	4
BLOOD_Leukemia	UBTD1 →	+0.211	+0.115	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK2N1 by Positive regulation of fibroblast growth factor receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →