Positive regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRM2, ELK3, and NPTN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast growth factor receptor signaling pathway activity versus MRM2 in OVARY (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MRM2 →	-0.832	-0.154	.002	.001	3	7
BREAST	ELK3 →	+1.417	+0.298	<.001	.003	3	6
BONE	NPTN →	+1.303	+0.460	.007	<.001	3	6
STOMACH	EMP1 →	+3.584	+0.182	<.001	.005	3	5
BONE	FRMD6 →	+3.538	+0.460	<.001	<.001	3	5
BONE	MT2A →	+5.123	+0.579	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045743 vs MRM2 — OVARY

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