Positive regulation of DNA repair

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, PHIP_S911, and ADNP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA repair activity versus SMC3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC3 →	+0.309	+0.033	.003	.008	3	8
LUAD	PHIP_S911 →	+0.563	+0.036	<.001	<.001	3	8
GBM	ADNP →	+0.408	+0.046	<.001	<.001	3	8
LUAD	DNMT1 →	+0.257	+0.031	.003	<.001	3	8
OV	CTNNBL1 →	+0.251	+0.030	.001	.005	3	7
GBM	SMC1A →	+0.280	+0.031	.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045739 vs SMC3 — GBM

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