Positive regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAR1B, CA12, and AVPI1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA repair activity versus SAR1B in LUNG_SCLC (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SAR1B →	-0.865	-0.193	.001	.001	3	6
SOFT_TISSUE	CA12 →	-2.720	-0.140	.003	.009	3	5
OVARY	AVPI1 →	-1.610	-0.163	.003	.003	2	6
LUNG_NSCLC_LUSC	FAM184A →	+2.146	+0.187	<.001	.002	3	5
STOMACH	CORO6 →	+1.517	+0.235	.002	.009	3	4
BLOOD_Leukemia	PAX5 →	+1.895	+0.085	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045739 vs SAR1B — LUNG_SCLC

Explore this scatter interactively →