Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAXE, RPL6, and RPL7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity versus NAXE in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NAXE →	+0.389	+0.056	<.001	<.001	3	5
BRCA	RPL6 →	-0.338	-0.024	.005	.005	2	6
BRCA	RPL7 →	-0.290	-0.029	.002	.001	3	5
LSCC	CES1 →	+0.790	+0.038	.001	<.001	3	5
COAD	EEF2 →	-0.162	-0.025	<.001	<.001	3	5
LSCC	ARFGAP3 →	-0.304	-0.062	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045736 vs NAXE — LSCC

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