Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A5, KLF15, and MYBPC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity versus SLC2A5 in GBM (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC2A5 →	-1.009	-0.461	<.001	<.001	3	4
LUAD	KLF15 →	+1.173	+0.148	<.001	.007	3	4
PDAC	MYBPC3 →	-0.302	-0.147	.003	.001	3	4
GBM	STXBP2 →	-0.512	-0.386	<.001	.006	3	4
GBM	MEOX2 →	+1.510	+0.427	.002	.001	3	4
CCRCC	SLC16A3 →	-0.443	-0.335	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045736 vs SLC2A5 — GBM

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