Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAB2, SPIN1_S199, and PELP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity versus NAB2 in PDAC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NAB2 →	+0.322	+0.178	<.001	<.001	3	4
OV	SPIN1_S199 →	+0.609	+0.625	<.001	.002	2	4
LSCC	PELP1 →	+0.230	+0.410	<.001	.002	3	3
LSCC	SMC6 →	+0.192	+0.345	.002	<.001	3	3
UCEC	VGLL4_S268 →	+0.844	+0.252	<.001	.002	2	4
COAD	ZC3H18 →	+0.228	+0.286	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045736 vs NAB2 — PDAC

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