Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36L1, MYL9, and LOXL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFP36L1 grouped by Negative regulation of cyclin-dependent protein serine/threonine kinase activity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZFP36L1 →	-1.208	-0.888	.001	.001	3	6
LUNG_NSCLC_LUSC	MYL9 →	-4.774	-1.558	<.001	.003	3	5
LUNG_NSCLC_LUSC	LOXL2 →	-2.988	-1.381	.004	.008	2	6
KIDNEY	GCNT1 →	+1.677	+1.232	.007	.004	3	4
URINARY_TRACT	NDRG4 →	+3.109	+1.781	<.001	<.001	3	4
BLOOD_Leukemia	ACO1 →	-1.400	-1.055	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFP36L1 by Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity — CNS

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