Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APC, CDKN2A, and LATS1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity versus APC in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	APC →	+1.121	+0.137	<.001	<.001	3	14
STOMACH	CDKN2A →	+3.549	+0.118	<.001	<.001	3	13
OVARY	LATS1 →	+0.823	+0.107	<.001	<.001	3	13
LARGE_INTESTINE	LATS2 →	+1.308	+0.118	<.001	<.001	3	12
LUNG_SCLC	SHPRH →	+1.109	+0.144	<.001	<.001	3	12
LUNG_NSCLC_LUSC	HBS1L →	+1.012	+0.093	.001	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045736 vs APC — OVARY

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