Negative regulation of cyclin-dependent protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of cyclin-dependent protein serine/threonine kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, HNF4A, and SRPX, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKR1B1 grouped by Negative regulation of cyclin-dependent protein serine/threonine kinase activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AKR1B1 →	-0.286	-2.283	<.001	.002	3	2
OVARY	HNF4A →	+0.110	+2.283	.004	.002	3	1
OVARY	SRPX →	+0.486	+2.283	.002	.002	3	1
OVARY	F9 →	-0.186	-2.283	.002	.002	3	1
OVARY	KLF5 →	-0.503	-2.283	.006	.002	3	1
OVARY	NOBOX →	-0.280	-2.726	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKR1B1 by Negative regulation of cyclin-dependent protein serine/threonine kinase activity activity — OVARY

Explore this box plot interactively →