Positive regulation of protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS13C, LPP, and UTRN, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein catabolic process activity versus VPS13C in UVM (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	VPS13C →	+1.595	+0.030	<.001	<.001	3	34
THYM	LPP →	+1.311	+0.041	<.001	<.001	3	34
DLBC	UTRN →	+1.945	+0.061	<.001	.001	3	34
SCLC	AKAP13 →	+1.109	+0.045	<.001	<.001	3	34
THYM	PEAK1 →	+1.258	+0.043	<.001	<.001	3	34
SCLC	SSH1 →	+2.134	+0.064	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045732 vs VPS13C — UVM

Explore this scatter interactively →