Positive regulation of protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM11B, HSDL2, and CDKN1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMIM11B grouped by Positive regulation of protein catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SMIM11B →	-1.161	-0.115	.007	.006	2	5
STOMACH	HSDL2 →	-0.747	-0.157	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	CDKN1B →	-1.231	-0.192	.001	.003	3	4
SKIN	WDR5 →	-0.474	-0.123	.006	.003	3	4
OVARY	SLMAP →	-0.609	-0.105	.004	.009	3	3
LUNG_NSCLC_LUAD	CLDN23 →	+0.979	+0.126	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMIM11B by Positive regulation of protein catabolic process activity — STOMACH

Explore this box plot interactively →