Respiratory burst

Across TCGA patient cohorts, RNA activity of the Respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, PIK3R5, and DOK3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory burst activity versus MEFV in LSCC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEFV →	+0.767	+0.189	<.001	<.001	3	10
GBM	PIK3R5 →	+0.938	+0.180	<.001	<.001	3	10
GBM	DOK3 →	+0.871	+0.241	<.001	<.001	3	10
GBM	LILRB3 →	+0.892	+0.148	<.001	<.001	3	10
LUAD	ADGRG3 →	+0.871	+0.181	<.001	<.001	3	10
LUAD	CSF3R →	+1.098	+0.211	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045730 vs MEFV — LSCC

Explore this scatter interactively →