Respiratory burst

Across TCGA cell cohorts, RNA activity of the Respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVEN, MACO1, and ANTXR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AVEN grouped by Respiratory burst-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AVEN →	+1.023	+1.338	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MACO1 →	-0.918	-1.233	.001	.007	3	5
BREAST	ANTXR1 →	+2.193	+1.045	.001	<.001	3	5
BREAST	PRR5 →	-0.856	-0.634	<.001	.005	3	5
LIVER	C16orf95 →	+0.513	+1.318	.008	.009	3	4
LUNG_SCLC	ARID1A →	-0.696	-1.253	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AVEN by Respiratory burst activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →