Respiratory burst

Across TCGA cell cohorts, RNA activity of the Respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, RND3, and GGCT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory burst activity versus RAC2 in OESOPHAGUS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RAC2 →	+2.096	+0.393	<.001	<.001	3	7
OESOPHAGUS	RND3 →	+1.120	+0.302	.004	<.001	3	4
URINARY_TRACT	GGCT →	-1.156	-0.265	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CAMKMT →	-1.001	-0.326	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PJA1 →	+0.795	+0.335	.002	.004	3	4
BLOOD_Lymphoma	TINAGL1 →	+0.310	+0.246	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045730 vs RAC2 — OESOPHAGUS

Explore this scatter interactively →