Respiratory burst

Across TCGA cell cohorts, RNA activity of the Respiratory burst pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAC2, RAC1, and AP1B1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory burst activity versus RAC2 in OVARY (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RAC2 →	+2.912	+0.983	<.001	.004	3	10
BLOOD_Leukemia	RAC1 →	+0.659	+0.268	<.001	<.001	3	8
LARGE_INTESTINE	AP1B1 →	+0.645	+0.815	<.001	<.001	3	4
BLOOD_Leukemia	CEP57 →	-0.972	-0.271	.002	.007	3	4
OVARY	NCEH1 →	+2.097	+0.818	<.001	.002	3	4
BLOOD_Leukemia	PSMA6 →	+0.395	+0.439	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045730 vs RAC2 — OVARY

Explore this scatter interactively →