Positive regulation of cilium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB4, AP3D1, and SLC16A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB4 grouped by Positive regulation of cilium assembly-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZBTB4 →	+0.717	+0.291	.002	<.001	3	4
OVARY	AP3D1 →	-0.629	-1.147	<.001	<.001	3	4
BREAST	SLC16A6 →	-1.140	-0.829	.002	<.001	3	4
CNS	EML1 →	-1.506	-0.858	<.001	.005	3	4
BREAST	TSPAN13 →	-1.493	-0.896	.006	<.001	3	4
BREAST	PTPA →	-0.607	-0.795	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB4 by Positive regulation of cilium assembly activity — URINARY_TRACT

Explore this box plot interactively →