Positive regulation of cilium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR35, DNAJB9, and HADHA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cilium assembly activity versus WDR35 in BLOOD_Leukemia (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDR35 →	-0.991	-0.153	.002	.008	3	5
BLOOD_Myeloma	DNAJB9 →	-1.708	-0.276	.005	.006	3	5
UPPER_AERODIGESTIVE_TRACT	HADHA →	-0.901	-0.245	.009	.009	3	4
LUNG_NSCLC_LUAD	TCEA1 →	-0.856	-0.218	<.001	<.001	3	4
BLOOD_Leukemia	SH2B3 →	-0.862	-0.228	.001	<.001	3	4
BLOOD_Leukemia	SLC44A2 →	+1.578	+0.251	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045724 vs WDR35 — BLOOD_Leukemia

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