Positive regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-E, ZC3H13_S198, and CASP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid biosynthetic process activity versus HLA-E in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLA-E →	+0.446	+0.078	<.001	<.001	3	7
HNSC	ZC3H13_S198 →	-0.663	-0.065	.001	.004	3	7
GBM	CASP4 →	+0.578	+0.096	<.001	<.001	3	7
HNSC	SRRM2_T1043 →	-1.038	-0.058	<.001	.001	3	6
COAD	S100A8 →	+1.546	+0.053	<.001	<.001	3	6
GBM	GBP2 →	+0.530	+0.060	.007	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045723 vs HLA-E — GBM

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