Positive regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF233, NUDT21, and EMSY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid biosynthetic process activity versus ZNF233 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF233 →	-0.264	-0.643	.001	.001	3	4
BRCA	NUDT21 →	-0.539	-0.266	.001	<.001	3	4
BRCA	EMSY →	-0.454	-0.206	.009	.004	3	4
BRCA	FYTTD1 →	-0.521	-0.164	.001	.002	3	4
BRCA	POT1 →	-0.393	-0.178	<.001	.001	3	4
BRCA	NAA30 →	-0.405	-0.173	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045723 vs ZNF233 — COAD

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