Positive regulation of fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICAL2, SLCO1B3, and SEMA7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICAL2 grouped by Positive regulation of fatty acid biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MICAL2 →	-1.836	-0.692	<.001	.005	3	5
CNS	SLCO1B3 →	-1.322	-0.742	.005	<.001	3	3
LUNG_NSCLC_LUAD	SEMA7A →	-2.746	-1.038	<.001	<.001	3	3
CNS	SERINC2 →	-2.103	-0.663	<.001	<.001	3	3
CNS	ORAI3 →	-0.935	-0.557	.001	.006	3	3
CNS	EFCAB13 →	+0.674	+0.641	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICAL2 by Positive regulation of fatty acid biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →