Positive regulation of fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL4, HLCS, and ATP5MC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid biosynthetic process activity versus METTL4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	METTL4 →	-1.042	-1.437	<.001	.004	3	4
SKIN	HLCS →	-0.706	-1.415	<.001	<.001	3	4
STOMACH	ATP5MC2 →	+0.832	+0.870	.004	.005	3	4
BLOOD_Myeloma	ARHGEF10L →	-2.667	-1.418	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SNX9 →	-0.727	-1.877	.007	<.001	3	4
BLOOD_Leukemia	PLXNA1 →	-1.525	-0.904	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045723 vs METTL4 — UPPER_AERODIGESTIVE_TRACT

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