Positive regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HUWE1_S1903, TDP1, and EPS8_S298, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gluconeogenesis activity versus HUWE1_S1903 in CCRCC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HUWE1_S1903 →	-0.529	-0.074	<.001	.001	3	5
OV	TDP1 →	-0.490	-0.049	.009	.002	3	4
LSCC	EPS8_S298 →	-0.647	-0.080	.008	<.001	3	4
LSCC	HSPD1 →	+0.366	+0.064	.007	<.001	3	4
LSCC	PRDX6 →	+0.286	+0.062	.001	<.001	3	4
PDAC	SPRYD4 →	+0.269	+0.048	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045722 vs HUWE1_S1903 — CCRCC

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