Positive regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR20_S434, TCF4_S66, and TNS1_T775, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gluconeogenesis activity versus WDR20_S434 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WDR20_S434 →	-0.480	-0.345	<.001	<.001	3	3
UCEC	TCF4_S66 →	+0.688	+0.223	.001	<.001	3	3
UCEC	TNS1_T775 →	+0.636	+0.161	<.001	<.001	3	3
GBM	FLNB_S1988 →	-1.182	-0.512	<.001	<.001	3	3
GBM	POLR1G_S490 →	+0.507	+0.231	<.001	<.001	3	3
OV	ACIN1_S898 →	+0.947	+0.203	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045722 vs WDR20_S434 — BRCA

Explore this scatter interactively →