Positive regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARA, PRTFDC1, and OR52B6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPARA grouped by Positive regulation of gluconeogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPARA →	-0.498	-0.370	.001	.001	3	8
LUNG_NSCLC_LUAD	PRTFDC1 →	+0.164	+0.178	<.001	.002	3	5
BREAST	OR52B6 →	+0.244	+0.161	<.001	.007	3	5
BREAST	WDR5 →	-0.385	-0.232	.009	.002	3	5
BONE	SIRT1 →	-0.218	-0.431	.003	<.001	3	4
CNS	CYP27C1 →	-0.182	-0.223	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPARA by Positive regulation of gluconeogenesis activity — PANCREAS

Explore this box plot interactively →