Positive regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAI1, CYSTM1, and ZNF367, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAI1 grouped by Positive regulation of gluconeogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNAI1 →	+0.386	+0.167	.001	<.001	3	6
LUNG_NSCLC_LUSC	CYSTM1 →	+0.295	+0.136	<.001	.008	3	5
BREAST	ZNF367 →	+0.199	+0.076	<.001	.002	3	5
BLOOD_Leukemia	FRMD5 →	-0.180	-0.077	.003	.006	3	5
LARGE_INTESTINE	POLR1F →	+0.233	+0.086	.003	.005	3	4
LARGE_INTESTINE	ZNF551 →	-0.158	-0.073	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAI1 by Positive regulation of gluconeogenesis activity — URINARY_TRACT

Explore this box plot interactively →