Positive regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADIPOR2, ECD, and RPS12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gluconeogenesis activity versus ADIPOR2 in LARGE_INTESTINE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADIPOR2 →	-0.649	-0.777	.001	.004	3	5
OESOPHAGUS	ECD →	-0.681	-0.970	.003	.003	3	4
BLOOD_Myeloma	RPS12 →	-0.657	-1.547	.005	<.001	3	4
BLOOD_Myeloma	KCP →	-1.125	-0.994	.006	.009	3	4
OESOPHAGUS	LACTB2 →	-0.997	-1.010	<.001	<.001	3	4
OESOPHAGUS	CIB1 →	-1.103	-1.107	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045722 vs ADIPOR2 — LARGE_INTESTINE

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