Negative regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of gluconeogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, VCAN_S2116, and C1QTNF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gluconeogenesis activity versus VCAN in CCRCC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCAN →	+0.835	+0.040	<.001	<.001	3	6
CCRCC	VCAN_S2116 →	+0.797	+0.043	.006	<.001	3	6
BRCA	C1QTNF3 →	+1.401	+0.049	<.001	<.001	3	6
HNSC	PSMB1 →	-0.186	-0.050	.003	.002	3	6
GBM	HDGFL3 →	+0.360	+0.052	<.001	<.001	3	6
BRCA	ARHGEF17_S735 →	+0.521	+0.057	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045721 vs VCAN — CCRCC

Explore this scatter interactively →