Negative regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TROAP, KIF18B, and FOXM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gluconeogenesis activity versus TROAP in UCEC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TROAP →	+1.000	+0.871	<.001	<.001	3	5
UCEC	KIF18B →	+1.006	+0.943	<.001	<.001	3	5
UCEC	FOXM1 →	+0.837	+1.096	.001	<.001	3	4
LSCC	ARHGDIB →	-0.531	-0.431	.002	.002	3	4
LSCC	SOGA1 →	+0.749	+0.546	<.001	<.001	3	4
GBM	SERPINA1 →	-1.242	-0.826	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045721 vs TROAP — UCEC

Explore this scatter interactively →