Negative regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFRD1, TRIM11, and PPP1R37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFRD1 grouped by Negative regulation of gluconeogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IFRD1 →	-0.885	-0.592	.003	.008	3	4
PANCREAS	TRIM11 →	+0.521	+1.283	.001	<.001	3	4
BREAST	PPP1R37 →	+1.179	+0.866	<.001	<.001	3	4
BREAST	TOX2 →	-1.127	-0.594	.009	.002	2	5
BREAST	CRB3 →	+2.244	+0.814	.001	.001	3	4
BREAST	GCH1 →	+1.218	+0.896	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFRD1 by Negative regulation of gluconeogenesis activity — BREAST

Explore this box plot interactively →