Negative regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIS3, PIBF1, and TGDS, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid biosynthetic process activity versus DIS3 in SKCM (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DIS3 →	+1.068	+0.051	<.001	<.001	3	29
SKCM	PIBF1 →	+1.448	+0.054	<.001	<.001	3	29
UVM	TGDS →	+1.248	+0.037	<.001	<.001	3	29
SKCM	NUP58 →	+0.963	+0.049	<.001	<.001	3	29
THYM	ARHGEF7 →	+0.838	+0.052	<.001	<.001	3	28
UVM	SUPT20H →	+1.006	+0.044	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045717 vs DIS3 — SKCM

Explore this scatter interactively →