Negative regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH8, CDC25B, and ELK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid biosynthetic process activity versus MYH8 in PDAC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MYH8 →	-0.277	-0.128	.001	.001	3	4
GBM	CDC25B →	+0.354	+0.115	.005	<.001	3	3
COAD	ELK1 →	+0.363	+0.148	.002	.002	3	3
GBM	CIZ1 →	+0.254	+0.129	.002	<.001	3	3
GBM	NBPF20 →	+0.291	+0.152	<.001	.003	3	3
UCEC	ODF2-AS1 →	+0.814	+0.166	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045717 vs MYH8 — PDAC

Explore this scatter interactively →