Positive regulation of glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADH1B, C7, and FHL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell differentiation activity versus ADH1B in COAD (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADH1B →	+0.874	+0.205	.002	.001	3	4
UCEC	C7 →	+1.698	+0.229	<.001	<.001	2	5
BRCA	FHL1 →	+1.247	+0.171	<.001	.001	3	4
CCRCC	FOXD4L1 →	-0.183	-0.091	<.001	.003	3	4
COAD	CHRDL1 →	+1.047	+0.218	.006	<.001	2	4
COAD	ZSCAN5A →	-0.325	-0.188	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045687 vs ADH1B — COAD

Explore this scatter interactively →