Positive regulation of glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC20, HOXC8, and AIFM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC20 grouped by Positive regulation of glial cell differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	H2AC20 →	+0.240	+1.863	.006	<.001	3	4
PANCREAS	HOXC8 →	+0.261	+1.300	.001	<.001	3	3
LUNG_NSCLC_LUAD	AIFM1 →	-0.324	-0.897	.003	.003	3	3
LARGE_INTESTINE	FOXD2 →	+0.141	+1.202	.001	.001	3	3
BLOOD_Myeloma	NECTIN2 →	+0.282	+1.407	.004	.009	3	3
BLOOD_Myeloma	MTMR14 →	-0.262	-1.407	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC20 by Positive regulation of glial cell differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →