Positive regulation of glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTC1, NCBP1, and PKDREJ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell differentiation activity versus CRTC1 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CRTC1 →	+0.776	+0.995	.005	.003	3	5
OVARY	NCBP1 →	+0.909	+0.957	<.001	.009	3	4
LARGE_INTESTINE	PKDREJ →	-0.219	-0.826	.009	.009	3	3
PANCREAS	SLC7A5 →	+1.833	+0.798	<.001	.004	3	3
BLOOD_Lymphoma	RC3H2 →	+0.598	+0.978	.005	.002	3	3
BREAST	ERP44 →	+0.593	+0.810	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045687 vs CRTC1 — BLOOD_Lymphoma

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