Negative regulation of glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of glial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHSA1, SEPTIN4, and TLN1_S1201, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell differentiation activity versus AHSA1 in LSCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AHSA1 →	-0.247	-0.066	.002	<.001	3	6
GBM	SEPTIN4 →	+0.752	+0.067	.001	.003	3	6
LSCC	TLN1_S1201 →	+0.830	+0.068	<.001	<.001	3	6
BRCA	GSN →	+0.538	+0.048	.001	<.001	3	6
BRCA	MSRB3 →	+0.531	+0.050	.007	<.001	3	6
CCRCC	PRKG1 →	+0.486	+0.041	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045686 vs AHSA1 — LSCC

Explore this scatter interactively →