Negative regulation of glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERS5, HINFP, and ZNF34, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell differentiation activity versus CERS5 in CCRCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CERS5 →	+0.175	+0.624	.004	<.001	3	3
CCRCC	HINFP →	+0.270	+0.593	.001	.005	3	3
GBM	ZNF34 →	+0.326	+0.166	.005	.003	3	3
CCRCC	IGHVII-74-1 →	+0.484	+0.519	.002	.006	3	3
LUAD	CALHM6 →	-0.598	-0.422	.005	.008	3	3
UCEC	SNAP23P1 →	+0.571	+0.214	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045686 vs CERS5 — CCRCC

Explore this scatter interactively →