Negative regulation of glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHCR7, GSAP, and SMG6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHCR7 grouped by Negative regulation of glial cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DHCR7 →	-1.576	-1.608	.001	<.001	3	4
OVARY	GSAP →	+1.044	+0.964	.002	.005	3	4
BLOOD_Leukemia	SMG6 →	+0.971	+1.285	.006	.003	3	4
LARGE_INTESTINE	GRAMD2A →	+1.128	+1.004	.001	<.001	3	3
KIDNEY	GRTP1 →	+1.402	+1.417	.001	<.001	3	3
KIDNEY	WDFY3 →	+1.157	+1.278	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHCR7 by Negative regulation of glial cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →