Negative regulation of glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSCC1, H2BC15, and SULT1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell differentiation activity versus DSCC1 in BLOOD_Lymphoma (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DSCC1 →	-1.516	-0.432	.007	.001	3	5
BLOOD_Lymphoma	H2BC15 →	+1.329	+0.467	.002	<.001	3	4
LUNG_SCLC	SULT1A1 →	-3.327	-0.549	.006	.004	3	4
BLOOD_Lymphoma	NAE1 →	-0.591	-0.393	<.001	.006	3	3
BLOOD_Lymphoma	MTBP →	-1.073	-0.393	<.001	.006	3	3
BLOOD_Lymphoma	C1orf112 →	-1.096	-0.439	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045686 vs DSCC1 — BLOOD_Lymphoma

Explore this scatter interactively →