Regulation of glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIP2A, NTAN1, and TDP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell differentiation activity versus CIP2A in COAD (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CIP2A →	-0.554	-0.125	.006	.009	3	4
OV	NTAN1 →	-0.335	-0.142	.009	.001	3	3
COAD	TDP2 →	-0.439	-0.114	.001	.001	3	3
COAD	POLR3B →	-0.399	-0.166	.005	<.001	3	3
COAD	USF1P1 →	-0.126	-0.127	.005	.003	3	3
COAD	MIR924HG →	-0.220	-0.114	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045685 vs CIP2A — COAD

Explore this scatter interactively →