Regulation of glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIBAN2, CDC14A, and PPP1R14B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell differentiation activity versus NIBAN2 in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NIBAN2 →	+0.815	+1.095	<.001	<.001	3	4
SKIN	CDC14A →	+0.566	+0.782	.005	.008	3	4
LUNG_NSCLC_LUAD	PPP1R14B →	+0.414	+0.680	.004	.003	3	4
LUNG_SCLC	AMOTL2 →	+2.121	+1.035	.005	.004	3	4
LUNG_SCLC	RNF145 →	+0.842	+0.973	.001	.001	3	4
OVARY	BSG →	+0.786	+1.091	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045685 vs NIBAN2 — SKIN

Explore this scatter interactively →