Positive regulation of epidermis development

Across TCGA patient cohorts, RNA activity of the Positive regulation of epidermis development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVPL, PPL, and SCEL_S91, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epidermis development activity versus EVPL in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EVPL →	+0.527	+0.052	.002	.004	3	5
BRCA	PPL →	+0.624	+0.036	<.001	<.001	3	5
PDAC	SCEL_S91 →	+1.380	+0.049	<.001	<.001	3	5
UCEC	VSNL1 →	+0.969	+0.051	<.001	.006	3	5
UCEC	MMP2 →	+0.937	+0.064	<.001	.008	3	5
PDAC	LMNA →	+0.307	+0.037	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045684 vs EVPL — UCEC

Explore this scatter interactively →