Positive regulation of epidermis development

Across TCGA patient cohorts, RNA activity of the Positive regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK1A, UNG, and CCDC112, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epidermis development activity versus DIPK1A in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DIPK1A →	-0.588	-0.800	<.001	.001	3	4
LSCC	UNG →	+0.514	+0.402	.003	.005	3	4
OV	CCDC112 →	+0.636	+0.373	<.001	<.001	3	4
PDAC	TRMT5 →	+0.290	+0.479	.004	.009	3	4
PDAC	THAP9 →	+0.323	+0.567	<.001	<.001	3	4
OV	CNRIP1 →	-0.826	-0.282	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045684 vs DIPK1A — GBM

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