Positive regulation of epidermis development

Across TCGA cell cohorts, RNA activity of the Positive regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2CD3, GPR137, and HABP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epidermis development activity versus C2CD3 in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C2CD3 →	+0.648	+0.156	.003	.001	3	4
OVARY	GPR137 →	+0.586	+0.125	.004	.003	3	4
BLOOD_Lymphoma	HABP4 →	-1.245	-0.174	.004	.002	3	4
BONE	NUMA1 →	+1.168	+0.269	.003	.007	3	4
OESOPHAGUS	UGT8 →	+2.161	+0.279	.006	.005	3	4
BLOOD_Lymphoma	RTKN2 →	+1.500	+0.155	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045684 vs C2CD3 — OVARY

Explore this scatter interactively →